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; Bgu  _ ` @ۇ4?a Pfs@=tps://wa8.my0e0ch.g.ukl!lpl cpnhsccr.[pxs`b\s@_1udXffv@{HYPERLIN `bcd'\\n<}}fQf Xp\c0f1\uWHIRASBϫCOA{aWXZ@45pb[n 0LAnn 1;A!0 ip @`m 0i3~Ѱ][u[ BPgP\#^@^pP b[o=Op/sFHITUWORStu` ;A b `itwk@@\U]Rl!]q `bjf[p\^O߇ϕߖ__y6a `e1dgPye@- `ze:@ 11pt;Qdc @708"Sf yAri0@4-@ ;0;ed f`0f`s2coAgoA/@Ïv???g1<48^⺁e350e/?֟uv?ԯտ׿mxD:ߥ?o_y{ۯܿп5/ j_oOѬ_'o<2088_OnO_/{/ "_O_#o _!o"*$O?O'()2OQ3_}ShBST/o19,_ _8?09A?;>?@H$EOF_GoOI?OLMNUoPOPTIMISEpIR6LOT\  Z?o\PodoefbOjk/l?/?aS/[wr?%&tuvx-.E}/~?g?DamǞaend1anE_?O_/K_LϖϞ_NwP-sucialOOS/T?UO_Wocdߙo\]ϭc_og_ho/Ono߽߾_v?wOoSF!new si0s inۀ 0pI0lQd, PScotR a/!W01ly~_/ϏO?ؿُ//¯鿚?O_(Pqase𸀨 toe~pup hyouҩ.ԠmzaR0n~pulӀHSne/~rmisPCpPce.?O/?O_ O_o?o_o%O#_$o&o-?CE(,?4&ݏ3o+/4?K@glds{gz}j?kOl_mox/y?zOߌ/=uwB36?PӠyEgeP`-fGyDAFЦP;!0zeD12p-^d@`0`s`_zo/Rߡ祐>v plG D b(09410)@]pJEEpC@rkAB#ρߩoɻ5jPS_ϓ*ro/?Oo//߫?O_oo_o܏߻/ßį̟O_o˯үӿg?0Q35կxHc@h R%uG` `y_oo?OO/?OZ"Og"_o/?O_.snOSG?!P ~Fp0 | Ski?Da :8L?aG@Roa !u !E1 6LHOO_/&) o  -./6/?9:;B=?oFEe_%/G.hfepb:P0a.Pe~QQts@nhs.nefield4RfSp~H {HYPERLINK PQ}}S!Sprs@\cf1\ul-YURMφZ/a-OE[\]/#$aO^F_&'eB1 eac,/-?hjl?12345C7gryt{>?}~DEGHIJWLM/mPi@tp://w.XQukRoST_cVW̒`?oocooirϧ1pb}j\lT!/pq߬_ouvw/x?yOz_|߽Ͽ_oŏƟȿ.Sig1"up U@Pecxeiv!p R0w R@te ϔݖCXs8.-UnQ0e2.m@ubsc@be?u=04af4ddPe330cP38e@b 5&Xp;id=1a71ed9apWhHRA!`aԠ.o˿菤/O_oo1@bodyppZZя'pv da߰Ӑ-@g all" clasA P@siz <`ow pcӍ  wt}fp iFs e;gT0 0Tgoti 0luԠ pft8px U@p@1.1875bhӠg@4bwth!93b s0 1/&o /?O?_o !23"?#O_234568#$1%O)'o()*+,-./0:;O5?@9PQR/S?TOU_A$2BFoDEFGHJKL/M?NOW_XoYZ[7\]Vm_noopqr^o$3_cbcd/e?fOg_hoijktuvwxz09z/{?tOύߎ{$4}?_oχ߈/?2/?O$5_ϟߠ/?O_ooϮ?O_oʏO$6߻/?OX@O_o}A͟ίϿ7!h07!7+ڣA%/}58D}pNew Site Amendment, Implementation Information Dear Professor Pearse Thank you for submitting an amendment to add one or more new sites to your project If you have listed new sites in any other UK nations we will forward the information to the national coordinating function(s) for nations where the new site(s) are being added. In Northern Ireland, Scotland and Wales, NHS/HSC R&D offices will be informed. What Happens Next? Please set up the new site(s) as per the guidance found within IRAS <https://www.myresearchproject.org.uk/help/hlpnhshscr.aspx> . Please note that processes change from time to time so please use the most up to date guidance about site set up. If your study is supported by a research network, please contact the network as early as possible to help support set up of the new site(s). IRAS Project ID: 209688 Short Study Title: OPTIMISE II Date complete amendment submission received: 25 January 2018 Sponsor Amendment Reference Number: 4 Sponsor Amendment Date: 8 January 2018 Amendment Type: Non-substantial For new sites in Northern Ireland, Scotland and/or Wales only: Please start to set up your new sites. Sites may not open until NHS management permission is in place. For new sites in England only: For studies which already have HRA Approval: This email also constitutes HRA Approval for the amendment, and you should not expect anything further from the HRA. Please start to set up your new sites. Sites may not open until the site has confirmed capacity and capability (where applicable). For studies which do not yet have HRA Approval: HRA Approval is pending and you will receive confirmation of HRA Approval. You can start the process of setting up the new site but cannot open the study at the site until HRA Approval is in place and the site has confirmed capacity and capability (where applicable). If you have any questions relating to setting up sites in England, please direct these to hra.approval@nhs.net <mailto:hra.approval@nhs.net> . If you have any questions relating to setting up sites in Northern Ireland, Scotland or Wales, please direct these to the relevant national coordinating function <https://www.myresearchproject.org.uk/help/hlpnhshscr.aspx> . Note: you may only implement changes described in the amendment notice. Please do not hesitate to contact me if you require further information. Kind regards Jemima Clarke Health Research Authority Ground Floor | Skipton House | 80 London Road | London | SE1 6LH E.hra.amendments@nhs.net <mailto:hra.amendments@nhs.net> W. www.hra.nhs.uk <http://www.hra.nhs.uk> Sign up to receive our newsletter HRA Latest. <http://nhs.us8.list-manage2.com/subscribe?u=04af4dde330becaf38e8eb355&i d=1a71ed9a1e> "name": "English (United States)" }, "@source": "Exchange", "LanguageScores": { "English": 97.06602 }, "@EntityId": "6a232b6c-1ba4-432e-a94d-923814c22a33", "@correlationTrail": "AssetId=91fd6408-5aea-4075-ab31-38e9080d9329;ExtractionId=773b3b3e-ea4e-427e-9890-817af8cdef45;EntityId=6a232b6c-1ba4-432e-a94d-923814c22a33", "@extractionTimeUtc": "2018-01-31T14:15:46.4273009Z" } ][ { "@type": "M2HClassifier", "@source": "HumanAuthor", "@outputVersion": "1.0", "domains": { "@type": "ItemList", "itemListOrder": "ItemListUnordered", "M2HOutput": [ "1" ] }, "@EntityId": "e885b81c-412d-4557-8bb2-38219de4b96e", "@correlationTrail": "AssetId=91fd6408-5aea-4075-ab31-38e9080d9329;ExtractionId=773b3b3e-ea4e-427e-9890-817af8cdef45;EntityId=e885b81c-412d-4557-8bb2-38219de4b96e", "@extractionTimeUtc": "2018-01-31T14:15:46.4273009Z" } ]tAi8okbb6cvgxDBGxR1+NkHxNGCEX5YbuZVC2FdrUM6Er+T4HulFRifCQVfO58H38A+qpVT4vvfPy5Z4vdyLlpm4vv7sGWemasd0VXFPLnIzJ3jybrBDbe6HoTTbs8cyzMqJQAJV3di/uKxpCHDZ4HDBMf1uGBrOxho5EHjWe4ir2nyJBPXjHINPsVGsLw0awvPu0SGgQJaSB8KII4JGtHWnDxBkfhjiAoMfkC1O7eA41mxgU1SrsKOhg9lJ576PFPoZAETrlXeW4cNXmKAR9u8cSdZgoSJmAymQlKH0icCCBhumWqI6GAHURZHDktpMFocusedInboxFeatureSet_21??? ? ?SV=15.20.0464.012;SN=DB5PR07MB1398;CT=2018-01-31T14:15:46.442Z;ODF=Inbox;AR=True;ARULE=WellKnownBulkSenderLocalpart, LocalpartPatterns;CPMC=0;IFIC=True;UC=ClutterInactive;MV=<null>;HDTR=2216;HMV=5010;HDTF=-205152104Email25.152.2.141138.37.6.62 -1801739945? -941679919? -1838443004? 812894953? 935867832? 483718820? -1262136544? -636403744? -230561347? 1973882207? 2073099130? 812211223? -715465007? 383278532? 670869959? -928584884? 488810802? 474371546? -645461281? 761581170? 1554871224? -820585871? 865201769? -104506445? -456693833? -451567365? 822659474? -373046220 s 6587987747!,DLg4D>r\eDAPJ|`+10J -1352434247? -1425520741*? -1307347238T? 898329109T? 1173260152T? 1559606841T? 2010703354? 562184828T? 789906169T? -205152104? -655821989(? -1040989670(? 1181474517("? 1601236884("? -1677198541("? -2061710734("? 483561593 -1650083956 1078847788 1212219856 -1931400828 LB;TFR=NotForking;FIXUP=3.377;Version=Version 15.20 (Build 464.0), Stage=H12;UP=10;DP=1C5;QT=91;DB5PR07MB1398;27:TDFCZwODE7SxOBLQpfWn3VumaKtNcHfywA/Z/jLZ+8WV6T4k759zbkw/6kpfKCENO8zHAFY+CZoX4unYl3wlv5JUmUFJ68huHU31V23HRPgyOvrSxhV+aqHkQitTV7kW["ExtractionId","773b3b3e-ea4e-427e-9890-817af8cdef45","TeeEngineVersion","50.0.0","BuildNumber","20180122.7","ChangesetNumber","20180122.7","Locale","en-US","MessageId","\u003cf6c4c085-320c-4061-9f15-dfb236005e2e@VE1EUR01FT009.eop-EUR01.prod.protection.outlook.com\u003e","ReferenceTime","2018-01-31T14:15:45.0000000+00:00","Flights","TEE1FlightA;TEE2FlightB;TEE2Flight_5;TEE1FlightFirst3;TEE1FlightFirst6;RequestControl;CommitmentsTreatmentLowThreshold","StartTime","2018-01-31T14:15:46.4116760Z","EndTime","2018-01-31T14:15:46.4273009Z"]enAnonymousVE1EUR01FT009.eop-EUR01.prod.protection.outlook.compass (client-ip=82.118.225.66; envelope-from=noreply@harp.org.uk; helo=genesis.bgocloud.com) ExtractLanguage1.0M2HClassifier1.0ExtractLanguageM2HClassifier "&zK54hHKNh[{ "@context": "http://schema.org", "type": "M2HClassifier", "entities": [ { "@type": "M2HClassifier", "@source": "HumanAuthor", "@outputVersion": "1.0", "domains": { "@type": "ItemList", "itemListOrder": "ItemListUnordered", "M2HOutput": [ "1" ] }, "@EntityId": "e885b81c-412d-4557-8bb2-38219de4b96e", "@correlationTrail": "AssetId=91fd6408-5aea-4075-ab31-38e9080d9329;ExtractionId=773b3b3e-ea4e-427e-9890-817af8cdef45;EntityId=e885b81c-412d-4557-8bb2-38219de4b96e", "@extractionTimeUtc": "2018-01-31T14:15:46.4273009Z" } ] },{ "@context": "http://schema.org", "type": "ExtractLanguage", "entities": [ { "@type": "ExtractLanguage", "@context": "http://schema.microsoft.com", "@outputVersion": "1.0", "Language": { "@type": "Language", "Locale": "en-US", "name": "English (United States)" }, "@source": "Exchange", "LanguageScores": { "English": 97.06602 }, "@EntityId": "6a232b6c-1ba4-432e-a94d-923814c22a33", "@correlationTrail": "AssetId=91fd6408-5aea-4075-ab31-38e9080d9329;ExtractionId=773b3b3e-ea4e-427e-9890-817af8cdef45;EntityId=6a232b6c-1ba4-432e-a94d-923814c22a33", "@extractionTimeUtc": "2018-01-31T14:15:46.4273009Z" } ] }]15.020180122.7p.dias@qmul.ac.uknoreply@harp.org.ukp.dias@qmul.ac.ukp.dias@qmul.ac.uknoreply@harp.org.uknoreply@harp.org.ukPriyanthi Diashra.amendments@nhs.net4DCED194FD254E0CA2B84CA369E09974-HHX6804DCED194FD254E0CA2B84CA369E09974-HHX680hra.amendments@nhs.nethra.amendments@nhs.net/O=EXCHANGELABS/OU=EXCHANGE ADMINISTRATIVE GROUP (FYDIBOHF23SPDLT)/CN=RECIPIENTS/CN=4DCED194FD254E0CA2B84CA369E09974-HHX680EXnoreply@harp.org.ukSMTPܧ@B+//O=EXCHANGELABS/OU=EXCHANGE ADMINISTRATIVE GROUP (FYDIBOHF23SPDLT)/CN=RECIPIENTS/CN=4DCED194FD254E0CA2B84CA369E09974-HHX680p.dias@qmul.ac.ukNew Site Amendment, Implementation Information Dear Professor Pearse Thank you for submitting an amendment to add one or more new sites to your project If you have listed new sites in any other UK nations we will forward the information to the K {L/*V<f6c4c085-320c-4061-9f15-dfb236005e2e@VE1EUR01FT009.eop-EUR01.prod.protection.outlook.com>92109B1E3095D84799969E15CE8F0534@eurprd07.prod.outlook.comwMNMĔȮw*Р>x M(Hӑ,eInboxnoreply@harp.org.ukSMTPSMTP:NOREPLY@HARP.ORG.UKhra.amendments@nhs.net+nThra.amendments@nhs.netSMTPnoreply@harp.org.uk/O=EXCHANGELABS/OU=EXCHANGE ADMINISTRATIVE GROUP (FYDIBOHF23SPDLT)/CN=RECIPIENTS/CN=4DCED194FD254E0CA2B84CA369E09974-HHX680EXReceived: from DB5PR07MB0933.eurprd07.prod.outlook.com (2603:10a6:6:2f::19) by DB5PR07MB1398.eurprd07.prod.outlook.com with HTTPS via DB6P190CA0006.EURP190.PROD.OUTLOOK.COM; 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Summary of the scoring: * 1.1 URIBL_GREY Contains an URL listed in the URIBL greylist * [URIs: list-manage2.com] * -0.0 SPF_PASS SPF: sender matches SPF record * 1.1 MIME_HTML_ONLY BODY: Message only has text/html MIME parts * 0.1 MISSING_MID Missing Message-Id: header * 0.6 HTML_MIME_NO_HTML_TAG HTML-only message, but there is no HTML tag * 0.0 T_PDS_FROM_2_EMAILS No description available. * -0.1 TXREP TXREP: Score normalizing based on sender's reputation X-QM-Scan-Virus: ClamAV says the message is clean X-QM-Body-MD5: b297d07c321eb5eb7d1216a83f20eb6d (of first 20000 bytes) X-SpamAssassin-Score: 3.9 X-SpamAssassin-SpamBar: +++ X-SpamAssassin-Report: The QM spam filters have analysed this message to determine if it is spam. We require at least 5.0 points to mark a message as spam. This message scored 3.9 points. Summary of the scoring: * 1.1 URIBL_GREY Contains an URL listed in the URIBL greylist * [URIs: list-manage2.com] * -0.0 SPF_HELO_PASS SPF: HELO matches SPF record * 1.0 SPF_SOFTFAIL SPF: sender does not match SPF record (softfail) * 1.1 MIME_HTML_ONLY BODY: Message only has text/html MIME parts * 0.1 MISSING_MID Missing Message-Id: header * 0.6 HTML_MIME_NO_HTML_TAG HTML-only message, but there is no HTML tag * 0.0 T_PDS_FROM_2_EMAILS No description available. * -0.1 TXREP TXREP: Score normalizing based on sender's reputation X-QM-Scan-Virus: ClamAV says the message is clean Message-ID: <f6c4c085-320c-4061-9f15-dfb236005e2e@VE1EUR01FT009.eop-EUR01.prod.protection.outlook.com> Return-Path: noreply@harp.org.uk X-MS-Exchange-Organization-Network-Message-Id: 8c354b7a-b934-4868-4b4e-08d568b51e12 X-EOPAttributedMessage: 0 X-EOPTenantAttributedMessage: 569df091-b013-40e3-86ee-bd9cb9e25814:0 X-MS-Exchange-Organization-MessageDirectionality: Incoming X-Forefront-Antispam-Report: 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